Patients With PAH Often Face a Delayed Diagnosis and Inadequate Treatment1

Delayed pulmonary arterial hypertension diagnosisDelayed pulmonary arterial hypertension diagnosis

The 2022 ESC/ERS Guidelines recommend combination therapy for treatment of PAH at diagnosis and follow-up depending on risk status4†

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REVEAL was a US-based, observational registry involving 55 academic- and community-based treatment centers. 3515 patients enrolled between March 2006 and December 2009. REVEAL was funded and sponsored by Actelion Pharmaceuticals US, Inc.1,5

In patients with idiopathic PAH, heritable PAH, PAH-CTD, or drug-associated PAH and without cardiopulmonary comorbidities.4

ERS=European Respiratory Society; ESC=European Society of Cardiology; PAH=pulmonary arterial hypertension; PAH-CTD=PAH associated with connective tissue disease; REVEAL=Registry to EValuate EArly and Long-term PAH Disease Management.

References: 1. Badesch DB, Raskob GE, Elliott CG, et al. Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest. 2010;137(2):376-387. 2. Didden EM, Lee E, Wyckmans J, et al. Time to diagnosis of pulmonary hypertension and diagnostic burden: a retrospective analysis of nationwide US healthcare data. Pulm Circ. 2023;13(1):e12188. doi:10.1002/pul2.12188 3. Brown LM, Chen H, Halpern S, et al. Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL Registry. Chest. 2011;140(1):19-26. 4. Humbert M, Kovacs G, Hoeper MM, et al; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Heart J. 2022;43(38):3618-3731. 5. McGoon MD, Miller DP. REVEAL: a contemporary US pulmonary arterial hypertension registry. Eur Respir Rev. 2012;21(123):8-18.

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